5-amino-2-fluorobenzoic acid

5-amino-2-fluorobenzoic acid - Names and Identifiers

Name	5-amino-2-fluorobenzoic acid
Synonyms	BUTTPARK 191-52 RARECHEM AL BO 1979 5-Amino-2-fluorobenziocacid 2-FLUORO-5-AMINOBENZOICACID 5-AMINO-2-FLUOROBENZOIC ACID 5-Amino-2-fluorobenzioc acid 5-Amino-2-Fluorobenzioc Acid 5-AMINO-2-FLUOROBENZIOC ACID 3-AMINO-6-FLUOROBENZOIC ACID 5-amino-2-fluorobenzoic acid 5-Amino-2-fluoro-benzoic acid 3-(Difluoromethoxy)-1,1,1,2,2-pentafluoropropane Difluoromethyl 2,2,3,3,3-pentafluoropropyl ether propane, 3-(difluoromethoxy)-1,1,1,2,2-pentafluoro-
CAS	56741-33-4
InChI	InChI=1/C7H6FNO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,9H2,(H,10,11)

5-amino-2-fluorobenzoic acid - Physico-chemical Properties

Molecular Formula	C7H6FNO2
Molar Mass	155.13
Density	1.430±0.06 g/cm3(Predicted)
Melting Point	190 °C
Boling Point	351.3±27.0 °C(Predicted)
Flash Point	166.3°C
Vapor Presure	1.54E-05mmHg at 25°C
pKa	2.41±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.606
MDL	MFCD00077449

5-amino-2-fluorobenzoic acid - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37 - Wear suitable gloves.
HS Code	29163990
Hazard Note	Irritant

5-amino-2-fluorobenzoic acid - Introduction

5-amino-2-fluorobenzoic acid is an organic compound with the chemical formula C7H6FNO2. It is a white crystalline solid, stable at room temperature. The following is a description of its nature, use, preparation and safety information:

Nature:
1. Appearance: 5-amino-2-fluorobenzoic acid is a white crystalline solid.
2. Solubility: It has low solubility in water and can be slightly soluble in organic solvents such as ethanol and ketone.
3. Thermal stability: It has good thermal stability and is not easy to decompose during heating.

Use:
5-amino-2-fluorobenzoic acid is an important intermediate in organic synthesis and is commonly used in the pharmaceutical and dye industries.
1. Pharmaceutical applications: It can be used to synthesize some drugs, such as clozapine.
2. Dye application: It can be used as a dye precursor for the synthesis of some colored dyes.

Preparation Method:
The preparation methods of 5-amino-2-fluorobenzoic acid mainly include the following:
1. Fluorination reaction: 2-fluorobenzoic acid and ammonia are reacted together with a catalyst to obtain 5-amino-2-fluorobenzoic acid.
2. diazo reaction: first prepare the diazo compound of 2-fluorobenzoic acid, and then react with ammonia to generate 5-amino-2-fluorobenzoic acid.

Safety Information:
The safety information on 5-amino-2-fluorobenzoic acid needs further research and experimental verification. In use should pay attention to the following points:
1. Avoid contact: avoid contact with skin, eyes and respiratory tract. Rinse with clean water immediately after contact.
2. Storage Note: Store in a dry, cool place, away from fire and flammable materials.
3. operation note: in the use of the process should wear protective gloves, glasses and masks, to ensure good ventilation.

Last Update：2024-04-09 21:54:55